Dual matrilineal geographic distribution of Korean type 2 diabetes mellitus-associated-11,377 G adiponectin alleleopen access
- Authors
- Choi, Jee-Hye; Min, Na Young; Park, Sang Kil; Gavaachimed, Lkhagvasuren; Ko, Young Jong; Han, Sung Hoon; Kim, Kyung Yong; Kim, Kijung; Lee, Kwang Ho; Park, Ae Ja
- Issue Date
- Dec-2014
- Publisher
- SPANDIDOS PUBL LTD
- Keywords
- type 2 diabetes mellitus; single nucleotide polymorphism; haplotype; adiponectin; hepatocyte nuclear factor 4 alpha; phosphoenolpyruvate carboxykinase 1; glucokinase; mitochondrial DNA
- Citation
- MOLECULAR MEDICINE REPORTS, v.10, no.6, pp 2993 - 3002
- Pages
- 10
- Journal Title
- MOLECULAR MEDICINE REPORTS
- Volume
- 10
- Number
- 6
- Start Page
- 2993
- End Page
- 3002
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11545
- DOI
- 10.3892/mmr.2014.2639
- ISSN
- 1791-2997
1791-3004
- Abstract
- The present study was performed to identify the susceptible single nucleotide polymorphisms (SNPs) for the prediction of Korean type 2 diabetes mellitus (T2DM) and to clarify the matrilineal origin of Korean T2DM-specific SNPs. Fourteen SNPs from the adiponectin (ADIPOQ), hepatocyte nuclear factor 4 alpha, phosphoenolpyruvate carboxykinase 1 and glucokinase genes in the Korean population were analyzed. Only one SNP, -11,377 C/G on the ADIPOQ gene, was finally determined to be responsible for the incidence of Korean T2DM (P=0.028). The G-T-T-A haplotype at positions -11,377, +45, +276 and +349 on the ADIPOQ gene was also associated with a high incidence of Korean T2DM (P=0.023). In addition, the susceptibility of Korean individuals to T2DM appears to be affected by their matrilineal origin. Of note, the group of Southern origin, consisting of mitochondrial DNA macrohaplogroups F and R, was predisposed to T2DM, whereas the group of Northern origin, consisting of haplogroups A and Y, was resistant to T2DM. This implied that the differential genetics between the two groups, which were formed from the initial peopling of the proto-Korean population via Southern and Northern routes to the present time, may explain their differing susceptibility to T2DM. In conclusion, from Southern Asia Northward, a matrilineal origin of Korean individuals appears to be responsible for the prevalence Of Korean T2DM caused by the -11,377 G allele.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
- College of Medicine > College of Medicine > 1. Journal Articles
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