Hydrogel-Based Ultra-moisturizing Cream Formulation for Skin Hydration and Enhanced Dermal Drug Delivery
- Authors
- Lee, Sang Gon; Kim, Sung Rae; Cho, Hye In; Kang, Mean Hyung; Yeom, Dong Woo; Lee, Seo Hyun; Lee, Sangkil; Choi, Young Wook
- Issue Date
- Oct-2014
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- hydrogel-based cream; moisturizer; skin hydration; topical delivery; skin permeation; skin distribution
- Citation
- BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.37, no.10, pp 1674 - 1682
- Pages
- 9
- Journal Title
- BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Volume
- 37
- Number
- 10
- Start Page
- 1674
- End Page
- 1682
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/11754
- DOI
- 10.1248/bpb.b14-00458
- ISSN
- 0918-6158
1347-5215
- Abstract
- To develop an external vehicle for skin hydration and enhanced dermal drug delivery, a hydrogel-based ultra-moisturizing cream (HUMC) was successfully formulated with carbopol 934P, urea, Tinocare GL, grape seed oil, and other excipients. The HUMC showed plastic flow behavior due to a gel structure with a cream base. Different types of drug-free vehicles such as a hydrogel, conventional cream (CC), and three HUMCs were prepared and subjected to an in vivo skin hydration test on a hairless mouse using a corneometer. Hydration effect (Delta AU) was in the order of HUMC2>HUMC1 >= CC>HUMC3>hydrogel. Using nile red (NR) and 5-carboxyfluorescein (5-CF) as lipophilic and hydrophilic fluorescent probes, respectively, in vitro skin permeation and accumulation studies were conducted using Franz diffusion cells. The values of steady-state flux (J(ss), ng/h/cm(2)) were obtained: 74.8 (CC), 145.6 (HUMC1), and 161.9 (HUMC2) for NR delivery; 6.8 (CC), 8.3 (HUMC1), and 10.9 (HUMC2) for 5-CF delivery. The amounts retained in the skin at 12 h (Q(r), ng/cm(2)) were determined: 86.4 (CC) and 102.0 (HUMC2) for NR; and 70.1 (CC) and 195.6 (HUMC2) for 5-CF. Confocal microscopy was used to visualize the distribution of the fluorescent probes. NR tended to be localized into the deeper part of the skin with adipose tissue whereas 5-CF localized in the upper layer of the skin. Thus we propose that HUMC2 is an efficacious vehicle for skin hydration and enhances dermal delivery of lipophilic and hydrophilic drugs.
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