Detailed Information

Cited 13 time in webofscience Cited 19 time in scopus
Metadata Downloads

Ellagic Acid Identified through Metabolomic Analysis Is an Active Metabolite in Strawberry ('Seolhyang') Regulating Lipopolysaccharide-Induced Inflammation

Authors
Lee, JaehooKim, SugyeongNamgung, HyejuJo, Young-HeeBao, ChengChoi, Hyung-KyoonAuh, Joong-HyuckLee, Hong Jin
Issue Date
May-2014
Publisher
AMER CHEMICAL SOC
Keywords
strawberry; ellagic acid; metabolomics; inflammation; murine macrophage cells
Citation
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.62, no.18, pp 3954 - 3962
Pages
9
Journal Title
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume
62
Number
18
Start Page
3954
End Page
3962
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12235
DOI
10.1021/jf4038503
ISSN
0021-8561
1520-5118
Abstract
This study employed the metabolomic approach to identify the key constituent exerting anti-inflammatory activity in murine macrophage RAW 264.7 cells. Among the six different fractions (SF1-SF6) of the strawberry 'Seolhyang', SF4 showed more significant inhibition on iNOS expression than SF3, and ellagic acid was determined as the most significant different component between SF4 and SF3 using orthogonal partial least-squares discriminant analysis. Ellagic acid (0.3 and 1.0 mu M) and SF4 (100 mu g/mL) were found to regulate the same inflammatory mediators, inhibitory kappa B (I kappa B) and mitogen-activated protein kinases (MAPKs), which led to the reduction of tumor necrosis factor (TNF-alpha), interleukin-1 beta (IL-1 beta), and iNOS expressions. These results demonstrate that ellagic acid from strawberry 'Seolhyang' is the major component playing a crucial role in inflammation, suggesting the possible application of metabolomic analysis to determining the key ingredients having biological functions in the complicated food matrix.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Pharmacy > School of Pharmacy > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Hong Jin photo

Lee, Hong Jin
대학원 (식품생명공학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE