Parallel and Combinatorial Liquid-Phase Synthesis of Alkylbiphenyls Using Pentaerythritol Support
- Authors
- Kim, Wang-Kyu; Jang, Jong-Hoon; Jo, Hyunjong; Park, Kwangyong
- Issue Date
- May-2014
- Publisher
- AMER CHEMICAL SOC
- Keywords
- pentaerythritol; traceless linker; multifunctional cleavage; combinatorial synthesis
- Citation
- ACS COMBINATORIAL SCIENCE, v.16, no.5, pp 225 - 231
- Pages
- 7
- Journal Title
- ACS COMBINATORIAL SCIENCE
- Volume
- 16
- Number
- 5
- Start Page
- 225
- End Page
- 231
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12273
- DOI
- 10.1021/co400136k
- ISSN
- 2156-8952
2156-8944
- Abstract
- Unfunctionalized alkylbiphenyls were fabricated by a parallel and combinatorial synthesis using pentaerythritol as a tetrapodal soluble support for a sulfonate-based traceless multifunctional linker system. Nickel N-heterocyclic carbenecatalyzed reactions of pentaerythritol tetrakis(biphenylsulfonate)s with primary alkylmagnesium bromides generated the allcylbiphenyl derivatives by desulfitative cleavage/cross-coupling of the C S bond without any "memory" of the attachment on the support. Though the reactions were completed with sufficient yields in 12 h at room temperature, even with only 1.5 equiv of nucleophiles, they still retained the benefits of facile isolation observed in polymer-supported reactions.
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Collections - College of Engineering > School of Chemical Engineering and Material Science > 1. Journal Articles
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