Hypopigmentary Effects of Ethyl P-Methoxycinnamate Isolated from Kaempferia galanga
- Authors
- Ko, Hyun-Ju; Kim, Hae Jong; Kim, Su Yeon; Yun, Hye-Young; Baek, Kwang Jin; Kwon, Nyoun Soo; Whang, Wan Kyun; Choi, Hye-Ryung; Park, Kyoung-Chan; Kim, Dong-Seok
- Issue Date
- Feb-2014
- Publisher
- WILEY-BLACKWELL
- Keywords
- melanin; Kaempferia galanga; ethyl p-methoxycinnamate; skin whitening
- Citation
- PHYTOTHERAPY RESEARCH, v.28, no.2, pp 274 - 279
- Pages
- 6
- Journal Title
- PHYTOTHERAPY RESEARCH
- Volume
- 28
- Number
- 2
- Start Page
- 274
- End Page
- 279
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12512
- DOI
- 10.1002/ptr.4995
- ISSN
- 0951-418X
1099-1573
- Abstract
- We isolated crystals from the chloroform fraction of an ethanol extract of Kaempferia galanga and identified it as ethyl p-methoxycinnamate through nuclear magnetic resonance analysis. In the present study, we found that ethyl p-methoxycinnamate significantly decreased melanin synthesis in B16F10 murine melanoma cells stimulated with -melanocyte stimulating hormone (-MSH). In a cell-free system, however, ethyl p-methoxycinnamate did not directly inhibit tyrosinase, the rate-limiting enzyme of melanogenesis. Instead, it inhibited tyrosinase activity in B16F10 cells in a dose-dependent manner. Furthermore, Western blot analysis showed that ethyl p-methoxycinnamate decreased microphthalmia-associated transcription factor and tyrosinase levels in -MSH-stimulated B16F10 cells. These results indicate that the pigment-inhibitory effect of ethyl p-methoxycinnamate results from downregulation of tyrosinase. Ethyl p-methoxycinnamate isolated from K. galanga could be developed as a skin whitening agent to treat hyperpigmentary disorders. Copyright (c) 2013 John Wiley & Sons, Ltd.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12512)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.