Comparison of the efficacy of 4-and 8-week lansoprazole treatment for ESD-induced gastric ulcers: a randomized, prospective, controlled study
- Authors
- Park, Ji Hoon; Baek, Eun Kyung; Choi, Chang Hwan; Lee, Kyung Hun; Kim, Beom Jin; Kim, Jeong Wook; Kim, Jae Gyu; Chang, Sae Kyung
- Issue Date
- Jan-2014
- Publisher
- SPRINGER
- Keywords
- Endoscopic submucosal dissection; Gastric ulcer; Proton pump inhibitor
- Citation
- SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, v.28, no.1, pp 235 - 241
- Pages
- 7
- Journal Title
- SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
- Volume
- 28
- Number
- 1
- Start Page
- 235
- End Page
- 241
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12615
- DOI
- 10.1007/s00464-013-3177-z
- ISSN
- 0930-2794
1432-2218
- Abstract
- Although endoscopic submucosal dissection (ESD) is widely used to treat gastric neoplasms, there is no consensus for the optimal treatment for ESD-induced ulcers. We compared efficacy between 4 and 8 weeks of lansoprazole treatment for iatrogenic gastric ulcers that developed after ESD. Eighty-four patients who were diagnosed with gastric adenoma or early gastric cancer were enrolled and randomly assigned to treatment with lansoprazole (30 mg/day) for 4 or 8 weeks. Eight weeks after ESD, we conducted follow-up endoscopy to compare ulcer stage and ulcer reduction ratio (dividing the ulcer dimension at 8 weeks by the initial ulcer dimension) between the two groups. From the 84 patients, 69 patients were included in the final analysis, with 34 in the 4-week group and 35 in the 8-week group. Eight weeks after ESD, there were no significant difference observed between the two groups in terms of the ulcer stage (68 % in the scar stage in the 4-week group vs. 69 % in the 8-week group, P = 0.93) or the ulcer reduction ratio (0.0081 +/- A 0.015 in the 4-week group vs. 0.0037 +/- A 0.008 in the 8-week group, P = 0.15). Also, in the subgroup analysis among the patients with large ulcers (> 30 mm), those parameters were not different. For ESD-induced gastric ulcers, treatment with lansoprazole for 4 weeks was as effective as treatment for 8 weeks. Considering cost-effectiveness, proton pump inhibitor therapy for 4 weeks may be sufficient for ESD-induced gastric ulcers.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.