Detailed Information
Cited 21 time in 
Cited 26 time in 
Cited 26 time in
Metadata Downloads
Novel inhibitory function of miR-125b in melanogenesis
- Authors
- Kim, Kyu-Han; Bin, Bum-Ho; Kim, Juewon; Dong, Son Eui; Park, Phil June; Choi, Hyunjung; Kim, Beom Joon; Yu, Seok Jong; Kang, Hyojin; Kang, Hak Hee; Cho, Eun-Gyung; Lee, Tae Ryong
- Issue Date
- Jan-2014
- Publisher
- WILEY-BLACKWELL
- Keywords
- microRNA; melanogenesis; miR-125b; melanoma; steady-state
- Citation
- PIGMENT CELL & MELANOMA RESEARCH, v.27, no.1, pp 140 - 144
- Pages
- 5
- Journal Title
- PIGMENT CELL & MELANOMA RESEARCH
- Volume
- 27
- Number
- 1
- Start Page
- 140
- End Page
- 144
- ISSN
- 1755-1471
1755-148X
- Abstract
- MicroRNAs are known to be the important regulators of skin physiology and considered as new therapeutic targets to treat skin diseases. In this study, miR-125b was identified as a potent regulator of steady-state melanogenesis. We found that the expression of miR-125b was inversely related to pigment levels. A miR-125b mimic decreased the expression of pigmentation-related gene and melanin content, implying that miR-125b functions to decrease pigmentation. Moreover, we observed that the reduction in miR-125b expression in pigmented cells was at least partially due to the hypermethylation of the MIR125B-1 promoter, and miR-125b expression was regulated by intracellular cAMP levels.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.