Anti-inflammatory activity of sulfate-containing phenolic compounds isolated from the leaves of Myrica rubra
- Authors
- Kim, Han Hyuk; Oh, Myeong Hwan; Park, Kwang Jun; Heo, Jun Hyeok; Lee, Min Won
- Issue Date
- Jan-2014
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Myrica rubra; Diarylheptanoid; Flavonoid; Sulfate; Inflammation; RAW 264.7 cells
- Citation
- FITOTERAPIA, v.92, pp 188 - 193
- Pages
- 6
- Journal Title
- FITOTERAPIA
- Volume
- 92
- Start Page
- 188
- End Page
- 193
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/12642
- DOI
- 10.1016/j.fitote.2013.10.007
- ISSN
- 0367-326X
1873-6971
- Abstract
- Three sulfated phenolic compounds, juglanin B (11R)-O-sulfate (1), myricetin 3'-O-sulfate (2), and ampelopsin 3'-O-sulfate (3), were isolated from the leaves of Myrica rubra. Compound 1 was a new sulfated lignan, 2 was a new sulfated flavone, and 3 was a known sulfated flavone. The structures of the new compounds (1 and 2) were determined by acid hydrolysis and spectroscopic methods, including IR, FAB-MS, 1D and 2D NMR. The inhibitory activities of compounds 1-3 and their hydrolysates (1a-3a) against LPS-induced cytokine (TNF-alpha, IL-1 beta and IL-6) production in macrophage RAW 264.7 cells were evaluated. The 2 new compounds (1 and 2) and their aglycones (1a and 2a) significantly reduced LPS-induced expression of iNOS and COX-2 proteins. (C) 2013 Published by Elsevier B.V.
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