COGNITION AND MEMORY FUNCTION OF TARAXACUM COREANUM IN AN IN VIVO AMYLOID-B-INDUCED MOUSE MODEL OF ALZHEIMER'S DISEASE
- Authors
- Lee, Ah Young; Yamabe, Noriko; Kang, Ki Sung; Kim, Hyun Young; Lee, Sanghyun; Cho, Eun Ju
- Issue Date
- 2014
- Publisher
- INST BIOLOSKA ISTRAZIVANJA SINISA STANKOVIC
- Keywords
- Taraxacum coreanum; Alzheimer's disease; cognition; memory
- Citation
- ARCHIVES OF BIOLOGICAL SCIENCES, v.66, no.4, pp 1357 - 1366
- Pages
- 10
- Journal Title
- ARCHIVES OF BIOLOGICAL SCIENCES
- Volume
- 66
- Number
- 4
- Start Page
- 1357
- End Page
- 1366
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14011
- DOI
- 10.2298/ABS1404357L
- ISSN
- 0354-4664
1821-4339
- Abstract
- We investigated whether the ethyl acetate fraction of Taraxacum coreanum (ETC) had a protective effect against memory impairment in an amyloid beta (A beta)-induced mouse model of Alzheimer's disease (AD). The formation of A beta in the brain is a hallmark of AD. We examined whether oxidative stress contributes to learning and memory deficits using the T-maze test, the object recognition test, and the Morris water maze test in mice injected with A beta. Cognition and memory function were significantly impaired in mice injected with A beta, as compared to the normal group. However, mice that received ETC orally at doses of 50 or 100 mg/kg/day for 2 weeks showed high recognition behavior of tasks. ETC may have prevented oxidative stress to the brain tissue by reducing lipid peroxidation levels and a NO scavenger. ETC could be useful for the prevention and treatment of AD.
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