Anti-oxidative and anti-inflammatory activities of caffeoyl hemiterpene glycosides from Spiraea prunifolia
- Authors
- Park, Sang Hee; Park, Kwan Hee; Oh, Myeong Hwan; Kim, Han Hyuk; Choe, Kang In; Kim, So Ra; Park, Kwang Jun; Lee, Min Won
- Issue Date
- Dec-2013
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Spiraea prunifolia; Rosaceae; Caffeoyl hemiterpenes; Hemiterpene glycosides; DPPH radical scavenging activity; NBT superoxide scavenging activity; NO production
- Citation
- PHYTOCHEMISTRY, v.96, pp 430 - 436
- Pages
- 7
- Journal Title
- PHYTOCHEMISTRY
- Volume
- 96
- Start Page
- 430
- End Page
- 436
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14101
- DOI
- 10.1016/j.phytochem.2013.09.017
- ISSN
- 0031-9422
- Abstract
- Activity guided isolation of a Spiraea prunifolia extract yielded five caffeoyl hemiterpene glycosides: 4'-(6-O-caffeoyl-beta-D-glucopyranosyl)-2'-methyl butyric acid, 1-O-caffeoyl-6-O-(4'-hydroxy-2'-methylene-butyroyl)-beta-D-glucopyranoside, 1,2-O-dicaffeoyl-6-O-(4'-hydroxy-2'-methylene-butyroyl)-beta-D-glucopyranoside, 1-O-caffeoyl-6-O-(4'-caffeoyl-2'-methylene-butyroyl)-beta-D-glucopyranoside, and 1-O-caffeoyl-6-O-(4'-caffeoyl-3'-hydroxy-2'-methylene-butyroyl)-beta-D-glucopyranoside, and nine known compounds. Structures were elucidated by analysis of 1D and 2D NMR spectra and FAB-MS. To evaluate the anti-oxidative and anti-inflammatory properties of all fourteen compounds, DPPH radical scavenging, NBT superoxide scavenging, and inhibition of nitric oxide production in LPS-stimulated RAW264.7 cells were examined. Three of the caffeoyl hemiterpene glycosides exhibited potent anti-oxidative and anti-inflammatory activities compared with Vitamin C and L-NMMA, which were used as positive controls. (C) 2013 Published by Elsevier Ltd.
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