Nitric oxide integrated polyethylenimine-based tri-block copolymer for efficient antibacterial activity
- Authors
- Park, Junghong; Kim, Jihoon; Singha, Kaushik; Han, Dong-Keun; Park, Hansoo; Kim, Won Jong
- Issue Date
- Nov-2013
- Publisher
- ELSEVIER SCI LTD
- Keywords
- N-Diazeniumdiolates; Nitric oxide delivery; Antibacterial activity; Methicillin-resistance
- Citation
- BIOMATERIALS, v.34, no.34, pp 8766 - 8775
- Pages
- 10
- Journal Title
- BIOMATERIALS
- Volume
- 34
- Number
- 34
- Start Page
- 8766
- End Page
- 8775
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14151
- DOI
- 10.1016/j.biomaterials.2013.07.064
- ISSN
- 0142-9612
1878-5905
- Abstract
- The work demonstrated a successful synthesis of nitric oxide (NO)-releasing material and its antibacterial effect on Gram-negative Escherichia coli (E. coli), Gram-positive Staphylococcus aureus (S. aureus) and methicillin-resistant S. aureus (MRSA). The polymeric support composed of thermosensitive Pluronic F68 having good biocompatibility and branched polyethylenimine (BPEI) housed N-diazeniumdiolates (NONOates) which could store and release NO under appropriate physiological condition. The developed F68-BPEI-NONOates releases a sufficient amount of NO under physiological condition to elicit effective killing of E. coli, S. aureus and MRSA. The antibacterial ability of the released NO was compared to un-treated control or unmodified F68 polymer by using confocal microscopy; F68-BPEI-NONOates demonstrated excellent antibacterial activity with in vitro low cytotoxicity. TEM investigation also revealed the destruction of bacteria membrane caused by NO. The effectiveness of F68-BPEI-NONOates against resistant strains such as MRSA provides a very simple but highly efficient strategy to combat drug-resistant bacterial infections. (C) 2013 Elsevier Ltd. All rights reserved.
- Files in This Item
-
- Appears in
Collections - College of ICT Engineering > School of Integrative Engineering > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.