The effect of calcium phosphate cement-silica composite materials on proliferation and differentiation of pre-osteoblast cells
- Authors
- Ahn, Geunseon; Lee, Jae Yeon; Seol, Dai-Wu; Pyo, Sung Gyu; Lee, Donghyun
- Issue Date
- Oct-2013
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Calcium phosphate cement; Silica; MC3T3-E1; Proliferation; Differentiation
- Citation
- MATERIALS LETTERS, v.109, pp 302 - 305
- Pages
- 4
- Journal Title
- MATERIALS LETTERS
- Volume
- 109
- Start Page
- 302
- End Page
- 305
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14216
- DOI
- 10.1016/j.matlet.2013.07.110
- ISSN
- 0167-577X
- Abstract
- Calcium phosphate cement (CPC) is increasingly being used for bone and tissue engineering in the medical and dental fields. In the current study, we investigated the ability of a CPC-silica composite to enhance the activity of cells by analyzing its effects on the proliferation and differentiation of MC3T3-E1, an osteoblast precursor cell line. We found that the CPC-silica composite materials with low silica content (5 wt%) promoted good initial cell adhesion and proliferation. In addition, the CPC-silica composite materials exhibited a higher capacity for stimulating osteogenic differentiation, which was assayed using alkaline phosphatase (ALP) activity and RT-PCR, than CPC alone. Therefore, we propose that 5 wt% silica content may serve as a useful component in calcium phosphate-based bone cements owing to its ability to promote osteoblast differentiation. (c) 2013 Elsevier B.V. All rights reserved.
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Collections - College of ICT Engineering > School of Integrative Engineering > 1. Journal Articles
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