Anti-oxidative and Anti-inflammatory Effects of Flavonoids from the Silk of Zea mays Linn
- Authors
- Oh, M. H.; Choe, K. I.; Cho, S. H.; Jeong, M. S.; Myung, S. C.; Seo, S. J.; Choi, S. E.; Lee, M. W.
- Issue Date
- Jul-2013
- Publisher
- ASIAN JOURNAL OF CHEMISTRY
- Keywords
- Zea mays Linn; Flavonoid; Anti-oxidative; Anti-inflammatory; Inducible nitric oxide synthase; Cyclooxygenase-2
- Citation
- ASIAN JOURNAL OF CHEMISTRY, v.25, no.8, pp 4293 - 4297
- Pages
- 5
- Journal Title
- ASIAN JOURNAL OF CHEMISTRY
- Volume
- 25
- Number
- 8
- Start Page
- 4293
- End Page
- 4297
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14483
- DOI
- 10.14233/ajchem.2013.13943
- ISSN
- 0970-7077
0975-427X
- Abstract
- Activity-guided isolation of the silk of Zea mays Linn (ZMS) yielded three flavonoids, chrysoeriol-6-C-beta-boivinopyranosyl-7-O-beta-glucopyranoside (1), chrysoeriol (2) and luteolin (3). Anti-oxidative activity was measured using the 2,2-diphenyl-1-picryl-hydrazyl and superoxide dismutase-like superoxide anion (generated by xanthine oxidase/hypoxanthine) scavenging assays. Anti-inflammatory activity was confined by quantifying the protein and mRNA levels of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated HaCaT cells using western blotting and real-time polymerase chain reaction. The results showed that luteolin 3 exhibited potent 2,2-diphenyl-1-picryl-hydrazyl (IC50 = 18.31 +/- 1.29 mu M) and superoxide dismutase-like superoxide anion scavenging activity (IC50 = 1.47 +/- 0.14 mu M) and dose-dependently inhibited the protein expression of inducible nitric oxide synthase and cyclooxygenase-2 as well as their mRNA levels.
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