Effect of Rubus coreanus Miguel on prostate tumour growth

Abstract

The rapidly increasing incidence of prostate cancer in Korea has increased awareness of preventive measures, such as dietary supplementation. Unripe Rubus coreanus Miguel (RCM) has been used to improve prostate health. Using nude mice transplanted with a prostate cancer cell line, we investigated whether RCM supplementation was beneficial for inhibiting the formation or growth of prostate tumour, and its mechanisms. RCM effectively restricted tumour growth compared to the control but had no effect on tumour initiation. Ripe and unripe RCM exerted significant reduction in tumour growth compared to the control. The reduction in tumour mass shown in the RCM groups was associated with increased active form of caspase-3, indicating an enhanced caspase-3-mediated apoptotic process. In addition, RCM demonstrated a strong antioxidant capacity through a decrease in lipid peroxidation products. In addition, RCM modulated the activity of endogenous antioxidant enzymes through modest changes. Collectively, our data indicate that RCM is a promising alternative supplementation for limiting the growth of prostate cancer, and its effect is likely to be achieved through the initiation of caspase-3-mediated apoptosis. The antioxidant properties of RCM appear to play an essential role in its anti-proliferative effect on prostate tumours. (C) 2013 Elsevier Ltd. All rights reserved.