Supercritical fluid extract from maca alleviates colitis induced by dextran sulfate sodium in mice
DC Field | Value | Language |
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dc.contributor.author | Cho, Jae Young | - |
dc.contributor.author | Choi, Eun Hye | - |
dc.contributor.author | Kang, Jung Il | - |
dc.contributor.author | Choi, Changsun | - |
dc.contributor.author | Chun, Hyang Sook | - |
dc.date.available | 2019-03-09T01:57:17Z | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.issn | 2092-6456 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14618 | - |
dc.description.abstract | The objective of this study was to investigate the possible protective effects of maca (Lepidium meyenii) extract (MLE) by supercritical fluid extraction on dextran sodium sulfate (DSS)-induced colitis. Experimental colitis was induced by giving male BALB/c mice 3% DSS in drinking water, and MLE (30 mg/kg BW), sulfasalazine (100 mg/kg BW) or vehicle were administered orally. DSS challenge caused significant body weight loss, rectal bleeding, diarrhea, shortened colon length, histological changes, and increased myeloperoxidase (MPO) activity in DSS-treated mice. Oral administration of MLE significantly relieved the symptoms of diarrhea and rectal bleeding, and reduced colonic MPO activity (p < 0.05). MLE treatment inhibited expression of several colonic proteins related to inflammatory responses, such as interleukin (IL)-1 beta, tumor necrosis factor-alpha, IL-6, and S100 calcium-binding protein A8, whose expressions were increased significantly by DSS treatment. These results suggest that MLE can alleviate DSS-induced colitis in mice by modulating colonic inflammatory mediators. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST | - |
dc.title | Supercritical fluid extract from maca alleviates colitis induced by dextran sulfate sodium in mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s10068-013-0156-z | - |
dc.identifier.bibliographicCitation | FOOD SCIENCE AND BIOTECHNOLOGY, v.22, no.3, pp 859 - 864 | - |
dc.identifier.kciid | ART001785180 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000321071000037 | - |
dc.identifier.scopusid | 2-s2.0-84879644383 | - |
dc.citation.endPage | 864 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 859 | - |
dc.citation.title | FOOD SCIENCE AND BIOTECHNOLOGY | - |
dc.citation.volume | 22 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | colitis | - |
dc.subject.keywordAuthor | dextran sulfate sodium | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | maca extract | - |
dc.subject.keywordAuthor | supercritical fluid extraction | - |
dc.subject.keywordPlus | INFLAMMATORY-BOWEL-DISEASE | - |
dc.subject.keywordPlus | FACTOR-KAPPA-B | - |
dc.subject.keywordPlus | INTESTINAL INFLAMMATION | - |
dc.subject.keywordPlus | LEPIDIUM-MEYENII | - |
dc.subject.keywordPlus | CROHNS-DISEASE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RATS | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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