Supercritical fluid extract from maca alleviates colitis induced by dextran sulfate sodium in mice
- Authors
- Cho, Jae Young; Choi, Eun Hye; Kang, Jung Il; Choi, Changsun; Chun, Hyang Sook
- Issue Date
- Jun-2013
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- colitis; dextran sulfate sodium; inflammation; maca extract; supercritical fluid extraction
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.22, no.3, pp 859 - 864
- Pages
- 6
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 22
- Number
- 3
- Start Page
- 859
- End Page
- 864
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/14618
- DOI
- 10.1007/s10068-013-0156-z
- ISSN
- 1226-7708
2092-6456
- Abstract
- The objective of this study was to investigate the possible protective effects of maca (Lepidium meyenii) extract (MLE) by supercritical fluid extraction on dextran sodium sulfate (DSS)-induced colitis. Experimental colitis was induced by giving male BALB/c mice 3% DSS in drinking water, and MLE (30 mg/kg BW), sulfasalazine (100 mg/kg BW) or vehicle were administered orally. DSS challenge caused significant body weight loss, rectal bleeding, diarrhea, shortened colon length, histological changes, and increased myeloperoxidase (MPO) activity in DSS-treated mice. Oral administration of MLE significantly relieved the symptoms of diarrhea and rectal bleeding, and reduced colonic MPO activity (p < 0.05). MLE treatment inhibited expression of several colonic proteins related to inflammatory responses, such as interleukin (IL)-1 beta, tumor necrosis factor-alpha, IL-6, and S100 calcium-binding protein A8, whose expressions were increased significantly by DSS treatment. These results suggest that MLE can alleviate DSS-induced colitis in mice by modulating colonic inflammatory mediators.
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