Detailed Information
Cited 1 time in 
Cited 1 time in 
Cited 1 time in
Metadata Downloads
Beneficial Effects of the Mixed Adjuvant of CpG plus Monophosphoryl Lipid A in Immunization with a Recombinant Protein Vaccine for Hepatitis A
- Issue Date
- Feb-2013
- Publisher
- KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
- Keywords
- adjuvant; cytokine; hepatitis A; immunoglobulin; recombinant vaccine
- Citation
- JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.56, no.1, pp 95 - 98
- Pages
- 4
- Journal Title
- JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
- Volume
- 56
- Number
- 1
- Start Page
- 95
- End Page
- 98
- ISSN
- 1738-2203
2468-0842
- Abstract
- In an effort to develop a new vaccine for hepatitis A, which is mainly transmitted via contaminated foods and water, recombinant virus protein 1 (VP1) of hepatitis A virus was used as an antigen. Several adjuvants in a single or a mixed form, i.e., alum, CpG oligodeoxynucleotide, monophosphoryl lipid A (MPL), alum plus MPL, and CpG plus MPL, were also tested for their immunological properties. When their effects on the production of VP1-specific IgG relative to that of total IgG and the levels of and balance between Th1- and Th2-type cytokine productions were compared, CpG plus MPL was found to have highly beneficial effects, providing a new insight in selection of adjuvant for development of a new vaccine.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.