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Cited 14 time in webofscience Cited 13 time in scopus
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Ultraviolet B-induced LGI3 secretion protects human keratinocytes

Authors
Lee, Seung HoonJeong, Yun-MiKim, So-YoungJeong, Hyo-SoonPark, Kyoung-ChanBaek, Kwang JinKwon, Nyoun SooYun, Hye-YoungKim, Dong-Seok
Issue Date
Sep-2012
Publisher
WILEY-BLACKWELL
Keywords
chronic allergic contact dermatitis; H1 receptor antagonist; H4 receptor antagonist
Citation
EXPERIMENTAL DERMATOLOGY, v.21, no.9, pp 716 - 718
Pages
3
Journal Title
EXPERIMENTAL DERMATOLOGY
Volume
21
Number
9
Start Page
716
End Page
718
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/15156
DOI
10.1111/j.1600-0625.2012.01550.x
ISSN
0906-6705
1600-0625
Abstract
Histamine facilitates development of eczematous lesions in chronic allergic contact dermatitis. In addition to the well-known corticosteroid treatments, H1 receptor (H1R) antagonists also have been used. This study observed effects of histamine H4 receptor (H4R) antagonist usage with H1R antagonist in a murine chronic allergic contact dermatitis model, developed by repeated percutaneous challenge to the dorsal skin with 2,4,6-trinitro-1-chlorobenzene (TNCB). The H1R antagonist olopatadine hydrochloride and/or the H4R antagonist JNJ7777120 was then administered. Combination therapy was more effective than H1R antagonist monotherapy. Serum IgE and levels of interleukin (IL)-4, IL-5 and IL-6 (Th2 cytokines) in eczematous lesions decreased with combined therapy. Combined therapy with H1R and H4R antagonists counteracts the disadvantages of each as monotherapeutic agents and potentially represents a new strategy for the treatment of chronic allergic contact dermatitis.
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