Engineered self-expander hydrogel for sustained release of drug molecules
- Authors
- Kim, Jieun; Hwang, Jangsun; Seo, Youngmin; Jo, Yeonho; Son, Jaewoo; Paik, Taejong; Choi, Jonghoon
- Issue Date
- Oct-2016
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Hydrogel; Self-expander; Breast cancer; Doxorubicin
- Citation
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.42, pp 121 - 125
- Pages
- 5
- Journal Title
- JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
- Volume
- 42
- Start Page
- 121
- End Page
- 125
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/1674
- DOI
- 10.1016/j.jiec.2016.07.033
- ISSN
- 1226-086X
1876-794X
- Abstract
- We synthesized a copolymer hydrogel composed of methyl methacrylate and N-vinyl-2-pyrrolidone and evaluated the in vitro release of the anticancer drug doxorubicin from this self-expanding hydrogel, under physiological conditions. The degree of expansion of the self-expanding copolymer was measured in various solutions. We induced drug adsorption into the methyl methacrylate and N-vinyl-2-pyrrolidone hydrogel by self-expansion, promoted by osmotic pressure. The antitumor effects of the released drug molecules were evaluated in MDA-MB-231 breast carcinoma cells. In conclusion, we provide evidence that this drug-containing self-expanding hydrogel may have the potential for biomedical applications including as an implant in tissue areas that require both physical support and anti-inflammatory drug treatment. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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Collections - College of ICT Engineering > School of Integrative Engineering > 1. Journal Articles
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