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Beauvetetraones A-C, phomaligadione-derived polyketide dimers from the entomopathogenic fungus, Beauveria bassiana
- Authors
- Lee, Seoung Rak; Kuefner, Michelle; Park, Minji; Jung, Won Hee; Choi, Sang Un; Beemelmanns, Christine; Kim, Ki Hyun
- Issue Date
- Jan-2019
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- ORGANIC CHEMISTRY FRONTIERS, v.6, no.2, pp 162 - 166
- Pages
- 5
- Journal Title
- ORGANIC CHEMISTRY FRONTIERS
- Volume
- 6
- Number
- 2
- Start Page
- 162
- End Page
- 166
- ISSN
- 2052-4129
2052-4129
- Abstract
- We report the isolation of two novel epimeric phomaligadione-derived polyketides, beauvetetraones A-B (1-2), from the entomopathogenic fungus Beauveria bassiana. Beauvetetraones A and B feature an unprecedented methylene-bridged phloroglucinol skeleton with a highly rearranged scaffold. In addition, a dimer of two phomaligadiones, named beauvetetraone C, was isolated for the first time from a natural source. The structures of compounds 1-3 including their absolute configurations were unambiguously assigned by NMR spectroscopic analyses, phenylglycine methyl ester (PGME) analysis, and quantum chemical ECD calculations. A putative biosynthetic pathway for beauvetetraones A-C is proposed.
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