Preparation of drug-immobilized anti-adhesion agent using visible light-curable alginate derivative containing furfuryl group
- Authors
- Noh, Seung-Hyun; Kim, Shin-Woong; Kim, Jae-Won; Lee, Tae-Hoon; Nah, Jae-Woon; Lee, Young-Gi; Kim, Mi-Kyung; Ito, Yoshihiro; Son, Tae-Il
- Issue Date
- Jan-2019
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Alginate; Anti-adhesion; Furfuryl group; Riboflavin; Visible light
- Citation
- INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v.121, pp 301 - 308
- Pages
- 8
- Journal Title
- INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Volume
- 121
- Start Page
- 301
- End Page
- 308
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18356
- DOI
- 10.1016/j.ijbiomac.2018.09.195
- ISSN
- 0141-8130
1879-0003
- Abstract
- This study demonstrated the anti-adhesion and wound healing effect of a visible light curable anti-adhesion agent using an alginate derivative modified with a furfuryl moiety. Visible light-curable furfuryl alginate (F-Alg) was prepared in conjugation with alginate and furfutylamine by an amide coupling reaction, and the conjugated F-Alg was characterized by H-1 NMR analysis. The cytotoxicity, cell adhesion, and cell permeability of the F-Alg were evaluated for use in anti-adhesion applications. Drug immobilization and protein release were assessed to verify whether the alginate derivatives and drugs were photo-immobilized. In in vivo anti-adhesion testing, the new anti-adhesion agent prepared in this study acted as a physical protective layer by forming a biofilm on the surgical site. Additionally, along with gradual decomposition of the photo-crosslinked alginate derivative, the immobilized drug was released, and additional effects such as accelerated wound healing are expected. Thus, visible light-curable F-Alg has good application potential as an anti-adhesion agent. (C) 2018 Elsevier B.V. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
- College of Medicine > College of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18356)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.