Antioxidant, anti-inflammatory, and anti-allergic activities of the sweet-tasting protein brazzein
- Authors
- Chung, Ju-Hee; Kong, Ji-Na; Choi, Hyo-Eun; Kong, Kwang-Hoon
- Issue Date
- Nov-2018
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Brazzein; Sweet tasting protein; Antioxidant activity; Anti-allergic effect; Anti-inflammatory activity; Functional sweetener
- Citation
- FOOD CHEMISTRY, v.267, pp 163 - 169
- Pages
- 7
- Journal Title
- FOOD CHEMISTRY
- Volume
- 267
- Start Page
- 163
- End Page
- 169
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18666
- DOI
- 10.1016/j.foodchem.2017.06.084
- ISSN
- 0308-8146
1873-7072
- Abstract
- Sweet-tasting proteins may be useful as low-calorie sugar substitutes in foods, beverages, and medicines. Brazzein is an attractive sweetener because of its high sweetness, sugar-like taste, and good stability at high temperature and wide pH ranges. To investigate the bioactivities of brazzein, the antibacterial, antifungal, antioxidant, anti-inflammatory, and anti-allergic activities were determined in vitro. Brazzein showed no antibacterial and antifungal activities, although it showed approximately 45% or greater similarity to defensin, which has antimicrobial effects, and drosomycin, which is used as an antifungal agent. However, brazzein exhibited strong antioxidant effects, showing ABTS radical scavenging activity (IC50 = 12.55 mu M) and DPPH activity (IC50 > 30 mu M). Brazzein also showed anti-inflammatory activity and anti-allergic activity in a beta-hexosaminidase assay (IC50 > 15 mu M) and cyclooxygenase-2 inhibition assay (IC50 = 12.62 mu M), respectively. These results suggest that brazzein has antioxidant, anti-inflammatory, and anti-allergic activities and considerable potential as a functional sweetener. (C) 2017 Elsevier Ltd. All rights reserved.
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