Temperature-Responsive Hydrogel-Coated Gold Nanoshellsopen access
- Authors
- Park, Hye Hun; Srisombat, La-ongnuan; Jamison, Andrew C.; Liu, Tingting; Marquez, Maria D.; Park, Hansoo; Lee, Sungbae; Lee, Tai-Chou; Lee, T. Randall
- Issue Date
- Jun-2018
- Publisher
- MDPI AG
- Keywords
- drug delivery; temperature responsive; gold nanoshell; hydrogel coating
- Citation
- Gels, v.4, no.2
- Journal Title
- Gels
- Volume
- 4
- Number
- 2
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/18703
- DOI
- 10.3390/gels4020028
- ISSN
- 2310-2861
2310-2861
- Abstract
- Gold nanoshells (similar to 160 nm in diameter) were encapsulated within a shell of temperature-responsive poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA)) using a surface-bound rationally-designed free radical initiator in water for the development of a photothermally-induced drug-delivery system. The morphologies of the resultant hydrogel-coated nanoshells were analyzed by scanning electron microscopy (SEM), while the temperature-responsive behavior of the nanoparticles was characterized by dynamic light scattering (DLS). The diameter of the P(NIPAM-co-AA) encapsulated nanoshells decreased as the solution temperature was increased, indicating a collapse of the hydrogel layer with increasing temperatures. In addition, the optical properties of the composite nanoshells were studied by UV-visible spectroscopy. The surface plasmon resonance (SPR) peak of the hydrogel-coated nanoshells appeared at similar to 800 nm, which lies within the tissue-transparent range that is important for biomedical applications. Furthermore, the periphery of the particles was conjugated with the model protein avidin to modify the hydrogel-coated nanoshells with a fluorescent-tagged biotin, biotin-4-fluorescein (biotin-4-FITC), for colorimetric imaging/monitoring.
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