Nitric oxide-releasing polymer incorporated ointment for cutaneous wound healing
- Authors
- Kang, Youngnam; Kim, Jihoon; Lee, Yeong Mi; Im, Sooseok; Park, Hansoo; Kim, Won Jong
- Issue Date
- Dec-2015
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Wound healing; Ointment; Nitric oxide; N-diazeniumdiolate
- Citation
- JOURNAL OF CONTROLLED RELEASE, v.220, pp 624 - 630
- Pages
- 7
- Journal Title
- JOURNAL OF CONTROLLED RELEASE
- Volume
- 220
- Start Page
- 624
- End Page
- 630
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/19057
- DOI
- 10.1016/j.jconrel.2015.08.057
- ISSN
- 0168-3659
1873-4995
- Abstract
- This work demonstrates the development of nitric oxide-releasing ointment and its potential on efficient wound healing. Nitric oxide-releasing polymer was successfully synthesized, which is composed of biocompatible Pluronic F127, branched polyethylenimine and 1-substituted diazen-1-ium-1,2-diolates. The synthesized nitric oxide-releasing polymer was incorporated into the PEG-based ointment which not only facilitated nitric oxide release in a slow manner, but also served as a moisturizer to enhance the wound healing. As compared to control groups, the nitric oxide-releasing ointment showed the accelerated wound closure with enhanced re-epithelialization, collagen deposition, and blood vessel formation in vivo. Therefore, this nitric oxide-based ointment presents the promising potential for the efficient strategy to heal the cutaneous wound. (C) 2015 Elsevier B.V. All rights reserved.
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Collections - College of ICT Engineering > School of Integrative Engineering > 1. Journal Articles
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