A nanosized delivery system of superparamagnetic iron oxide for tumor MR imaging
- Authors
- Lee, Eun Seong; Lim, Chaemin; Song, Ho-Taek; Yun, Jeong Min; Lee, Kyung Soo; Lee, Beom-Jin; Youn, Yu Seok; Oh, Young Taik; Oh, Kyung Teak
- Issue Date
- Dec-2012
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Polymeric micelle; Superparamagnetic iron oxide (SPIO); Hyperspectrum; T-2 relaxivity coefficients; Animal imaging
- Citation
- INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.439, no.1-2, pp 342 - 348
- Pages
- 7
- Journal Title
- INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Volume
- 439
- Number
- 1-2
- Start Page
- 342
- End Page
- 348
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/19933
- DOI
- 10.1016/j.ijpharm.2012.08.054
- ISSN
- 0378-5173
1873-3476
- Abstract
- Superparamagnetic iron oxide (SPIO) nanoparticles have been intensively investigated as MRI probes due to the noninvasive detection of in vivo pathological changes. In the study, a nanosized system for SPIO delivery to a tumor was prepared to overcome the common challenges of SPIO nanoparticles such as insufficient uptake of SPIO by specific cells due to instability, short half-life by macrophage, and low efficiency of internalization. SPIO with ca. 6 nm sizes as a MRI probe and PLA-PEG (5K-2K) as a bio-compatible stable system were prepared. The hydrophobic modified SPIO were loaded into the core of micelles and showed a stable dispersion with 140-170 nm particle sizes. The SPIO loading micelles showed higher relaxivity coefficients and increases of T-2 relaxation in vivo MR imaging. This SPIO delivery system with high stability and sensitivity can be a promising imaging formulation as MRI T-2 probes for tumor detection. (C) 2012 Elsevier B.V. All rights reserved.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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