Electrostatic charge conversion processes in engineered tumor-identifying polypeptides for targeted chemotherapy
- Authors
- Oh, Nam Muk; Kwag, Dong Sup; Oh, Kyung Taek; Youn, Yu Seok; Lee, Eun Seong
- Issue Date
- Feb-2012
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Tumor-identifying polypeptide; Cancer chemotherapy; Tumor extracellular pH; Photodynamic therapy
- Citation
- BIOMATERIALS, v.33, no.6, pp 1884 - 1893
- Pages
- 10
- Journal Title
- BIOMATERIALS
- Volume
- 33
- Number
- 6
- Start Page
- 1884
- End Page
- 1893
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20552
- DOI
- 10.1016/j.biomaterials.2011.11.026
- ISSN
- 0142-9612
1878-5905
- Abstract
- One of the current challenges in cancer chemotherapy is the ultra-sensitive identification of in vivo tumors. Herein, we report a new class of tumor-identifying polypeptides that can home in on in vivo tumors via an electrostatic charge conversion process occurring in the acidic milieu of a verity of tumors, which can be distinguished from receptor-interacting conventional tumor-homing peptides. We exploit the chemical coupling between polypeptides and therapeutic objects (drugs or particles) to carry out an antitumor study in nude mice, and find a significant increase in the efficiency of polypeptide-tagged objects in tumor uptake and inhibition, which is more significant than any known tumor-homing peptide system thus far developed. (C) 2011 Elsevier Ltd. All rights reserved.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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