Topical Hypopigmenting Agents for Pigmentary Disorders and Their Mechanisms of Actionopen access
- Authors
- Kim, Hyojin; Choi, Hye-Ryung; Kim, Dong-Seok; Park, Kyoung-Chan
- Issue Date
- Feb-2012
- Publisher
- KOREAN DERMATOLOGICAL ASSOC
- Keywords
- Hydroquinone; Hypopigmentation; Melanin
- Citation
- ANNALS OF DERMATOLOGY, v.24, no.1, pp 1 - 6
- Pages
- 6
- Journal Title
- ANNALS OF DERMATOLOGY
- Volume
- 24
- Number
- 1
- Start Page
- 1
- End Page
- 6
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20559
- DOI
- 10.5021/ad.2012.24.1.1
- ISSN
- 1013-9087
2005-3894
- Abstract
- Melanin is produced in melanocytes and stored in melanosomes. In spite of its beneficial sun-protective effect, abnormal accumulation of melanin results in esthetic problems. Hydroquinone, competing with tyrosine, is a major ingredient in topical pharmacological agents. However, frequent adverse reactions are amongst its major limitation. To solve this problem, several alternatives such as arbutin, kojic acid, aloesin, and 4-n-butyl resorcinol have been developed. Herein, we classify hypopigmenting agents according to their mechanism of action; a) regulation of enzyme, which is subdivided into three categories, i) regulation of transcription and maturation of tyrosinase, ii) inhibition of tyrosinase activity, and iii) post-transcriptional control of tyrosinase; b) inhibition of melanosome transfer, and c) additional mechanisms such as regulation of the melanocyte environment and antioxidant agents. (Ann Dermatol 24(1) 1 similar to 6, 2012)
- Files in This Item
-
- Appears in
Collections - College of Medicine > College of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.