Emergence of Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus Clinical Isolates Among Daptomycin-Naive Patients in Korea
- Authors
- Nam, Eun Young; Yang, Soo-Jin; Kim, Eu Suk; Cho, Jeong Eun; Park, Kyung-Hwa; Jung, Sook-In; Yoon, Nara; Kim, Dong-Min; Lee, Chang-Seop; Jang, Hee-Chang; Park, Yoonseon; Lee, Kkot Sil; Kwak, Yee Gyung; Lee, Jae Hoon; Park, Seong Yeon; Hwang, Joo-Hee; Kim, Moonsuk; Song, Kyoung-Ho; Kim, Hong Bin
- Issue Date
- Jun-2018
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- daptomycin resistance; Staphylococcus aureus; vancomycin
- Citation
- MICROBIAL DRUG RESISTANCE, v.24, no.5, pp 534 - 541
- Pages
- 8
- Journal Title
- MICROBIAL DRUG RESISTANCE
- Volume
- 24
- Number
- 5
- Start Page
- 534
- End Page
- 541
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/2075
- DOI
- 10.1089/mdr.2017.0212
- ISSN
- 1076-6294
1931-8448
- Abstract
- This study was conducted to assess emergence of daptomycin-nonsusceptible (DAP-NS) phenotype in DAP-naive patients with invasive Staphylococcus aureus (ISA) infections in Korea. A total of 208 S. aureus clinical isolates were selected from a previous prospective study on ISA infections and evaluated for DAP-NS. Although DAP has never been introduced in Korea, five DAP-NS S. aureus strains (2.4%) were identified among 208 S. aureus strains collected from ISA infections. The DAP-NS phenotype was observed only in methicillin-resistant S. aureus (MRSA) strains, but not in methicillin-susceptible S. aureus strains. One DAP-NS MRSA strain belonged to sequence type 72 (ST72) and four were ST5 MRSA strains, three of which were heteroresistant vancomycin (VAN)-intermediate S. aureus. All these five DAP-NS MRSA strains were from healthcare-associated infections without prior exposure to VAN within 30 days. While the ST72 MRSA strain exhibited DAP-NS phenotype via charge repulsion mechanism, four ST5 DAP-NS S. aureus strains had charge-independent DAP-NS mechanism. None of the five DAP-NS strains displayed significant increase in cell wall thickness, indicating that altered cell wall thickness was not associated with the observed DAP-NS phenotype.
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