Effectofdiets with mulberry leaf and Cudrania tricuspidata leaf powder supplements on blood glucose-related biomarkers in streptozotocin-induced diabetic rats
- Authors
- Park, Ju-Hun; Lee, Kyung-Won; Sung, Ki-Seung; Kim, Sung-Soo; Cho, Kyung-Dong; Lee, Bog-Hieu; Han, Chan-Kyu
- Issue Date
- 2012
- Publisher
- Korean Society of Food Science and Nutrition
- Keywords
- Blood glucose; Cudrania tricuspidata; Diabetic rats; Mulberry leaves; Triglyceride
- Citation
- Journal of the Korean Society of Food Science and Nutrition, v.41, no.6, pp 766 - 773
- Pages
- 8
- Journal Title
- Journal of the Korean Society of Food Science and Nutrition
- Volume
- 41
- Number
- 6
- Start Page
- 766
- End Page
- 773
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20838
- DOI
- 10.3746/jkfn.2012.41.6.766
- ISSN
- 1226-3311
2288-5978
- Abstract
- This study investigates the effects of diets with mulberry leaf and Cudrania tricuspidata leaf supplements on blood glucose-related biomarkers in streptozotocin-induced diabetic rats. Male diabetic Sprague-Dawley rats were divided into groups and fed several diets. Group A was fed a diet with a 10% supplement of mulberry leaves. Group B was fed a diet with a 10% supplement of mulberry leaves and an additional 10% supplement of Cudrania tricuspidata leaves. Group C was fed a diet with a 10% supplement of mulberry leaves and an additional 30% supplement of Cudrania tricuspidata leaves. Group D was fed a diet with a 10% supplement of Cudrania tricuspidata leaves. Group E was the DM control. All diets were based on AIN-93G diet and they all lasted 6 weeks. The blood glucose levels of groups B and C stayed similar to initial levels (reference blood glucose) for the experimental period, which was significantly lower than levels in groups A, D, and E at the 6th week (p<0.05). And the area under the blood glucose curve (AUC) was also significantly lower in groups B and C than in groups D and E (p<0.05). The fasting blood glucose level after the experiment was significantly lower in groups B and C (p<0.05), and the C-peptide content of group C was as high as 50 pmol/L on average. The HbA1c content was also significantly lower in groups A and B than in group E (p<0.05). The serum TG, AST, and ALT levels were significantly decreased in groups A, B, and D than in group E (p<0.05). From the findings, it is shown that a diet of 1:1 mulberry and Cudrania tricuspidata leaf supplements could improve blood glucose-related biomarkers.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Biotechnology & Natural Resource > School of Food Science and Technology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20838)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.