Topical formulation of retinyl retinoate employing nanostructured lipid carriers
- Authors
- Lee, S.G.; Jeong, J.H.; Kim, S.R.; Lee, K.M.; Ahn, B.K.; Kang, M.H.; Choi, Y.W.
- Issue Date
- Oct-2012
- Publisher
- Kluwer Academic Publishers
- Keywords
- High pressure homogenization; Nanostructured lipid carriers; Processing stability; Retinyl retinoate; Topical delivery
- Citation
- Journal of Pharmaceutical Investigation, v.42, no.5, pp 243 - 250
- Pages
- 8
- Journal Title
- Journal of Pharmaceutical Investigation
- Volume
- 42
- Number
- 5
- Start Page
- 243
- End Page
- 250
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/20922
- DOI
- 10.1007/s40005-012-0036-1
- ISSN
- 2093-5552
2093-6214
- Abstract
- Topical formulation of retinyl retinoate (RR) was developed with nanostructured lipid carriers (NLCs), composed of Compritol or Precirol as a solid lipid, canola oil as an oil, and Tween 80 as a surfactant. Hot high pressure homogenization method was efficiently employed to yield a homogenous nanodispersion in the size range of 230-300 nm with PDI values of <0. 2, regardless of lipid selection. Precirol-based NLC (P-NLC) showed higher drug entrapment than that of Compritol-based NLC (C-NLC): RR encapsulation efficiency (%) of P- and C-NLC was 97. 8 and 93. 8 in average, respectively; drug loading (mg RR/g lipid) was 89. 6 and 83. 3 in average, respectively. Processing condition at relatively low temperature of 60 °C was a key factor for maintaining RR stability. Drug release of P-NLC was greater than that of C-NLC, even though both NLCs revealed controlled release pattern. Therefore, P-NLC system was considered as a suitable vehicle for topical drug delivery, especially for heat-labile ingredient like RR. © 2012 The Korean Society of Pharmaceutical Sciences and Technology.
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