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Asymmetry of Motor Unit Number Estimate and Its Rate of Decline in Patients With Amyotrophic Lateral Sclerosis

Authors
Ahn, Suk-WonKim, Jee-EunSung, Jung-JoonLee, Kwang-WooHong, Yoon-Ho
Issue Date
Oct-2011
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
Motor unit number estimation; Amyotrophic lateral sclerosis; Asymmetry
Citation
JOURNAL OF CLINICAL NEUROPHYSIOLOGY, v.28, no.5, pp 528 - 532
Pages
5
Journal Title
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
Volume
28
Number
5
Start Page
528
End Page
532
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21204
DOI
10.1097/WNP.0b013e318231c9e0
ISSN
0736-0258
Abstract
This study was performed to investigate the asymmetry of motor unit number estimate (MUNE) and its longitudinal course in patients with amyotrophic lateral sclerosis. A modified statistical MUNE was performed at the hypothenar muscles bilaterally in a total of 135 patients, and 18 of these patients underwent a follow-up study. The degree of asymmetry varied considerably among those patients whose average MUNE of both sides was moderately reduced, whereas it tended to be low in those whose average MUNE was either severely reduced or close to normal. The rate of motor unit loss was also asymmetric, and two distinct patterns were identified. In patients whose MUNE was greater than 30 in both sides (n = 7), the rate of motor unit loss tended to be greater in the initially more affected side compared with the contralateral one, yielding the so-called lead phenomenon. In contrast, the other patients (n = 11) tended to show the opposite pattern of "catch-up," that is, MUNE declined faster in the initially less affected side compared with the contralateral one. This study shows that not only the MUNE but also the rate of motor unit loss are frequently asymmetric in amyotrophic lateral sclerosis patients.
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의과대학 (의학부(임상-서울))
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