Characteristics of 5-Hydroxytryptamine Receptors Involved in Contraction of Feline heal Longitudinal Smooth Muscle
- Authors
- Wang, YiYi; Park, Sun Young; Oh, Kyung Hoon; Min, Youngsil; Lee, Yun-Jeong; Lee, Seok-Yong; Sohn, Uy Dong
- Issue Date
- Oct-2011
- Publisher
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Keywords
- Ileum; Longitudinal smooth muscle; 5-HT; Contraction; Relaxation
- Citation
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, v.15, no.5, pp 267 - 272
- Pages
- 6
- Journal Title
- KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
- Volume
- 15
- Number
- 5
- Start Page
- 267
- End Page
- 272
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21240
- DOI
- 10.4196/kjpp.2011.15.5.267
- ISSN
- 1226-4512
2093-3827
- Abstract
- A number of studies have demonstrated that 5-hydroxytryptamine (5-HT) can induce muscle contraction or relaxation response and enhance secretion in the gastrointestinal tract via a multiplicity of 5-HT receptor subtypes. In the present study, we investigated the pharmacological characterization of the 5-HT-induced contractile response in longitudinal smooth muscle isolated from the feline ileum. Addition of 5-HT into muscle chambers enhanced the basal tone and spontaneous activity in a concentration-dependent manner. The neurotoxin tetrodotoxin did not alter the 5-HT-induced contraction of the longitudinal muscles. Neither atropine nor guanethidine affected the contraction. The 5-HT agonists, 5-methylserotonin hydrochloride and mosapride, also evoked concentration-dependent contractions. The 5-HT-induced contraction was enhanced by the 5HT(2) receptor antagonist ketanserin and the 5-HT, receptor antagonist ondansetron but was inhibited by the 5-HT(1) receptor antagonist methysergide and 5-HT(4) receptor antagonist GR113808. These results indicate that 5-HT(1) and 5-HT(4) receptors may mediate the contraction of the 5-HT-induced response and 5-HT(2) and 5-HT(3) receptors may mediate 5-HT-induced relaxation in feline ileal longitudinal smooth muscles.
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