Anti-obesity Effect of Carbon Dioxide Supercritical Fluid Extracts of Panax Ginseng C. A. Meyer
- Authors
- Woo, Hyun-Chul; Shin, Bok-Kyu; Cho, Inja; Koo, Hana; Kim, Mihyang; Han, Jaehong
- Issue Date
- Oct-2011
- Publisher
- KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
- Keywords
- anti-obesity; carbon dioxide; ginseng; polyacetylene; supercritical fluid extraction
- Citation
- JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.54, no.5, pp 738 - 743
- Pages
- 6
- Journal Title
- JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
- Volume
- 54
- Number
- 5
- Start Page
- 738
- End Page
- 743
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21246
- DOI
- 10.3839/jksabc.2011.111
- ISSN
- 1738-2203
2468-0842
- Abstract
- The root of Korean ginseng, Panax ginseng C. A. Meyer, has been known worldwide as a panacea for many centuries. Contradictory weight gain and loss effects in Korean ginseng led to the adoption of supercritical carbon dioxide extraction to assure the quality of food-grade anti-obesity ginseng products. Among different extraction conditions of CO, pressure (200 and 300 bars) and temperature (40, 50, and 60 degrees C), the highest extraction yield of 0.66% was obtained with 300 bars at 40 degrees C. To test anti-obesity effect, each supercritical fluid extract (SFE) was supplemented to the high-fat diet of male obese-prone C57BL/6J strain mice. All carbon dioxide SFEs of ginseng showed significant weight-loss effects in the tested mice. The average weights of normal and high fat diet mice were 28.7 +/- 2.0 and 35.0 +/- 1.6 g, respectively, after 10 weeks. Average weights of mice on SFE-supplemented high fat diets were between 24.5 +/- 1.4 and 25.9 +/- 13 g. SFEs obtained at 50 degrees C, and at both 200 and 300 bars, showed the most profound anti-obesity effect. Both SFEs showed 15 and similar to 30% weight loss for the normal and high-fat diet mice, respectively. The major component of the SFE was analyzed as polyacetylene compounds, and panaxydol and panaxynol were identified as major polyacetylene compounds. However, the anti-obesity effect of the ginseng SFEs was not correlated with contents of these two polyacetylene compounds in SFEs. No side-effects of ginseng SFEs were observed, and the anti-obesity effect was reversible.
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