Enhancement of Cardiac Myoblast Responses onto Electrospun PLCL Fibrous Matrices Coated with Polydopamine for Gelatin Immobilization
- Authors
- Shin, Young Min; Park, Hansoo; Shin, Heungsoo
- Issue Date
- Aug-2011
- Publisher
- SPRINGER
- Keywords
- surface modification; polydopamine; electrospinning; gelatin
- Citation
- MACROMOLECULAR RESEARCH, v.19, no.8, pp 835 - 842
- Pages
- 8
- Journal Title
- MACROMOLECULAR RESEARCH
- Volume
- 19
- Number
- 8
- Start Page
- 835
- End Page
- 842
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21376
- DOI
- 10.1007/s13233-011-0815-y
- ISSN
- 1598-5032
2092-7673
- Abstract
- A variety of surface modification techniques have been proposed to improve the cell-biomaterial interactions. On the other hand, these processes may cleave long-chained polymers, and compromise their mechanical properties. In this study, dopamine was used as a bridge molecule to immobilize gelatin on the poly(L-lactide-co-epsilon-caprolactone) (PLCL) fibrous matrices, which may then be used as a cell delivery carrier. The PLCL fibrous matrices coated with polydopamine by dipping (D-PLCL) can subsequently immobilize gelatin (GD-PLCL). The D-PLCL matrices showed minimal changes in the mechanical properties with a tensile strain of 251.0 +/- 33.4% and 247.8 +/- 32.1% before and after the coating process, respectively. The cellular activities on the fibrous matrices increased in the order of PLCL<G-PLCL<D-PLCL<GD-PLCL; the H9c2 myoblasts on the GD-PLCL matrices showed approximately two-times higher adhesion and spreading than those on the PLCL matrices, and the proliferation was significantly greater on the GD-PLCL matrices than on the other matrices. Therefore, polydopamine can effectively immobilize the bioactive functional groups on the surface of electrospun fibrous matrices for the development of a tissue specific cell delivery carrier.
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