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Identification of Proteins Differentially Expressed in Gastric Cancer Cells with High Metastatic Potential for Invasion to Lymph Nodes
- Authors
- Lee, Do Hee; Lee, Youra; Ryu, Joohyun; Park, Sung Goo; Cho, Sayeon; Lee, Je-Jung; Choi, Chan; Park, Byoung Chul
- Issue Date
- Jun-2011
- Publisher
- KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- Keywords
- AAT; AGR2; DBP; gastric cancer; metastasis; proteome
- Citation
- MOLECULES AND CELLS, v.31, no.6, pp 563 - 571
- Pages
- 9
- Journal Title
- MOLECULES AND CELLS
- Volume
- 31
- Number
- 6
- Start Page
- 563
- End Page
- 571
- ISSN
- 1016-8478
0219-1032
- Abstract
- In a search for proteins involved in cancer metastasis, we analyzed proteomes of the human gastric cancer cell OCUM-2M and its metastatic subline OCUM-2MLN. We observed that aspartate aminotransferase (AAT), D-site binding protein (DBP), and anterior gradient protein 2 (AGR2) are differentially expressed in metastatic OCUM-2MLN cells. Measurement of protein expression in clinical samples indicated that DBP and AAT are also down-regulated in metastatic adenocarcinoma. Additionally, urokinase-type tissue plasminogen activator is up-regulated in OCUM-2MLN cells and also in metastatic gastric cancer samples. Collectively, these results raise a possibility that AAT, DBP and AGR2 are functionally implicated in the invasiveness of gastric cancer cells.
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