Catechin-7-O-beta-D-Glucopyranoside Scavenges Free Radicals and Protects Human B Lymphoma BJAB Cells on H2O2-mediated Oxidative Stress
- Authors
- Baek, Jin-A; Son, Young-Ok; Fang, Minghao; Lee, Young Jae; Cho, Hyoung-Kwon; Whang, Wan Kyunn; Lee, Jeong-Chae
- Issue Date
- Feb-2011
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- apoptosis; catechin-7-O-beta-D-glucopyranoside; DNA damage; hydrogen peroxide; oxidative stress; red bean
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.20, no.1, pp 151 - 158
- Pages
- 8
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 20
- Number
- 1
- Start Page
- 151
- End Page
- 158
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21775
- DOI
- 10.1007/s10068-011-0021-x
- ISSN
- 1226-7708
2092-6456
- Abstract
- Catechin-7-O-beta-D-glucopyranoside (CA-G) was previously isolated from red bean (the seed of Phaseolus calcaratus cv. Roxburgh). This study examined the ability of CA-G to scavenge reactive oxygen species generated by cell-free systems and to protect cells from oxidative stress caused by hydrogen peroxide (H2O2). The mechanism by which CA-G exerts its antioxidant and anti-apoptotic action on H2O2-exposed cells was also investigated. CA-G treatment prevented H2O2-mediated apoptosis and inhibited the formation of single stand breaks in DNA in H2O2-exposed BJAB cells. CA-G suppressed mitochondrial stress and caspase activation caused by H2O2. Mechanistic experiments revealed that the antioxidant mechanism of CA-G on H2O2-mediated oxidative damage was due to the direct scavenging of hydroxyl radicals and/or to the chelation of metal ions that were used to produce hydroxyl radicals from H2O2 via the Fenton reaction. Collectively, these findings suggest beneficial roles of CA-G or CA-G-rich red bean on the protection from oxidative damage.
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