Effects of minocycline on Na+ currents in rat dorsal root ganglion neurons
- Authors
- Kim, Tae Hoon; Kim, Hong Im; Kim, Jungho; Park, Mijung; Song, Jin-Ho
- Issue Date
- Jan-2011
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Dorsal root ganglion; Minocycline; Na+ current; Tetracycline; Tetrodotoxin-resistant; Tetrodotoxin-sensitive
- Citation
- BRAIN RESEARCH, v.1370, pp 34 - 42
- Pages
- 9
- Journal Title
- BRAIN RESEARCH
- Volume
- 1370
- Start Page
- 34
- End Page
- 42
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21796
- DOI
- 10.1016/j.brainres.2010.11.038
- ISSN
- 0006-8993
1872-6240
- Abstract
- Minocycline is an inhibitor of microglial activation and proliferation. Minocycline suppresses pain-related behaviors in many different pain states, which correlates closely with its inhibition of microglial activation and subsequent release of pro-inflammatory mediators in the spinal cord. Na+ channels in dorsal root ganglion (DRG) neurons are implicated in the generation of inflammatory and neuropathic pain. To elucidate a possible peripheral mechanism of minocycline analgesia, effects of minocycline on tetrodotoxin-sensitive and tetrodotoxin-resistant Na+ currents in rat DRG neurons were investigated. Minocycline potently inhibited both types of Na+ currents with IC50 values of 350 nM and 410 nM, respectively. The inhibition was accompanied by a depolarizing shift of the activation voltage. However, minocycline slowed the inactivation and speeded up the recovery from inactivation. These results suggest minocycline may exert analgesia peripherally thorough Na+ channel inhibition in the primary afferent neurons as well as centrally through microglial inhibition in the spinal cord. (C) 2010 Elsevier B.V. All rights reserved.
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