Anti-asthmatic effects of phenylpropanoid glycosides from Clerodendron trichotomum leaves and Rumex gmelini herbes in conscious guinea-pigs challenged with aerosolized ovalbumin
- Authors
- Lee, Ji Yun; Lee, Jung Gun; Sim, Sang Soo; Whang, Wan-Kyunn; Kim, Chang Jong
- Issue Date
- Jan-2011
- Publisher
- ELSEVIER GMBH, URBAN & FISCHER VERLAG
- Keywords
- 1-O-caffeoyl glucoside; Clerodendron trichotomum; Acteoside; sRaw; Chemical mediators; BALF; Anti-asthmatic
- Citation
- PHYTOMEDICINE, v.18, no.2-3, pp 134 - 142
- Pages
- 9
- Journal Title
- PHYTOMEDICINE
- Volume
- 18
- Number
- 2-3
- Start Page
- 134
- End Page
- 142
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/21800
- DOI
- 10.1016/j.phymed.2010.06.014
- ISSN
- 0944-7113
- Abstract
- Clerodendron trichotomum leaves and Rumex aquatica herbs are used as a folk medicine for the treatment of inflammatory diseases, but their active ingredients are not known until now. We isolated caffeic acid and phenylpropanoid glycosides, 1-O-caffeoyl glycoside and acteoside [beta-(3',4'-dihydroxyphenyl) ethyl-O-alpha-L-rhamnopyranosyl(1 -> 3)-beta-D-(4-O-caffeoyl)-glucopyranoside] from their ethylacetate fractions, respectively, and evaluated their anti-asthmatic effects on the aerosolized ovalbumin (OA) challenge in the OA-sensitized guinea-pigs measuring the specific airway resistance (sRaw) during the immediate-phase response (IAR) and late-phase response (LAR), and also measured recruitment of leukocytes and chemical mediators on the bronchoalveolar lavage fluids (BALF) in LAR, as well as histopathological survey. Acteoside and 1-O-caffeoyl glycoside (25 mg/kg) significantly (P<0.05) inhibited sRaw by 32.14 and 26.79% in IAR, and by 55.88% and 52.94% in LAR, respectively, whereas caffeic acid (25 mg/kg) inhibited sRaw by 30.36% in IAR and 44.12% in LAR, compared to control, but with less effective than dexamethasone, disodium cromoglycate, and salbutamol, respectively. In addition, phenylpropanoid glycosides (25 mg/kg) significantly inhibited the recruitments of leukocytes, particularly neutrophils and eosinophils into lung, Furthermore, 1-O-caffeoyl glycoside, acteoside and caffeic acid significantly (P < 0.05) inhibited protein content at a dose of 25 mg/kg, and histamine content and PLA(2) activity at a dose of 50 mg/kg, in BALF. Acteoside had more active than caffeic acid and 1-O-caffeoyl glycoside. However, their anti-asthmatic effects were less than the reference drugs. These results indicated that caffeic acid and its glycosides (25 mg/kg) have anti-asthmatic effect as the same manner with dexamethasone and disodium cromoglycate. (C) 2010 Elsevier GmbH. All rights reserved.
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