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Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice: Involvements of 5-HT1A Receptor
- Authors
- Shin, Eun-Joo; Whang, Wan Kyunn; Kim, Sungun; Bach, Jae-Hyung; Kim, Jin-Man; Nguyen, Xuan-Khanh Thi; Nguyen, Thuy-Ty Lan; Jung, Bae Dong; Yamada, Kiyofumi; Nabeshima, Toshitaka; Kim, Hyoung-Chun
- Issue Date
- Aug-2010
- Publisher
- JAPANESE PHARMACOLOGICAL SOC
- Keywords
- parishin C; phencyclidine; 5-HT1A receptor
- Citation
- JOURNAL OF PHARMACOLOGICAL SCIENCES, v.113, no.4, pp 404 - 408
- Pages
- 5
- Journal Title
- JOURNAL OF PHARMACOLOGICAL SCIENCES
- Volume
- 113
- Number
- 4
- Start Page
- 404
- End Page
- 408
- ISSN
- 1347-8613
1347-8648
- Abstract
- Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviours in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C These effects were reversed by WAY 100635, a 5-HT1A-receptor antagonist. Consistently, parishin C showed high affinity at 5-HT1A receptor as well as a 5-HT1A-agonist activity in a 8-OH-DPAT-stimulated [35S]GTP-gamma S binding assay Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT1A receptors.
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