Occurrence and Fate of Fetal Lumbar Rib Induced by Scutellariae radix in Rats
- Authors
- Ko, Eun A.; Park, Won Sun; Lim, Inja; Yun, Jihyun; Kim, Jung-Ha; Kang, Young-Ku; Kim, Nari; Han, Jin; Bang, Hyoweon; Ko, Jae-Hong
- Issue Date
- Jun-2010
- Publisher
- WILEY
- Keywords
- Scutellariae radix; lumbar rib; transient fetal variation; teratogenicity; maternal toxicity; alkaline phosphatase
- Citation
- BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY, v.89, no.3, pp 201 - 206
- Pages
- 6
- Journal Title
- BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
- Volume
- 89
- Number
- 3
- Start Page
- 201
- End Page
- 206
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22440
- DOI
- 10.1002/bdrb.20242
- ISSN
- 1542-9733
1542-9741
- Abstract
- BACKGROUND: This study was conducted to evaluate the occurrence and fate of fetal lumbar rib induced by Scutellariae radix (SR) in rats. METHODS: Water extracts of SR were orally administered to pregnant rats from day 7 to day 17 of gestation at a dose of 186 mg/kg/day, equivalent to 25 g/kg of starting material, representing a 100-fold increase over typical human intake level. RESULTS: The incidence of fetal lumbar rib in the SR-treated group was increased on gestational day 20 and then decreased on postnatal day 50. The weight of fetuses in the SR-treated group tended to be less than that in the control group. Alkaline phosphatase in SR-treated dams was increased on gestational day 20, but was decreased on postnatal day 50. There were no significant differences between the vehicle control and SR-treated groups in maternal body weight, embryological, histopathological, hematological, and serum biochemical changes. CONCLUSIONS: The present data suggest that the appearance of lumbar rib induced by SR is a transient fetal variation rather than teratogenicity or maternal toxicity. Birth Defects Res (Part B) 89:201-206, 2010. (C) 2010 Wiley-Liss, Inc.
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