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The antioxidant and chemopreventive potentialities of Mosidae (Adenophora remotiflora) leaves

Authors
Kim, Ae-JungHan, Myung-RyunKim, Myung-HwanLee, MyoungsookYoon, Taek-JoonHa, Sang-Do
Issue Date
Feb-2010
Publisher
KOREAN NUTRITION SOC
Keywords
Mosidae (Adenophora remotiflora) leaves; antioxidant activity; cytotoxicity assay; tumor metastasis
Citation
NUTRITION RESEARCH AND PRACTICE, v.4, no.1, pp 30 - 35
Pages
6
Journal Title
NUTRITION RESEARCH AND PRACTICE
Volume
4
Number
1
Start Page
30
End Page
35
URI
https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22618
DOI
10.4162/nrp.2010.4.1.30
ISSN
1976-1457
2005-6168
Abstract
Our study focused on the antioxidant activities of Mosidae leaf ethanol extract (MLE) and included measurements of reducing power, total phenolic compounds, DPPH radical scavenging activity, and hydroxyl radical scavenging activity. In order to determine whether or not MLE evidences any chemopreventive activities, experimental lung metastasis was induced via the i.v. inoculation of colon26-M3.1 carcinoma cells into BALB/c mice. Additionally, we attempted to characterize any possible cytotoxic effects in murine normal splenocytes and tumor cells (B16-BL6 and colon26-M3.1). The total phenolic content and reducing capacity were measured at 39 mg/100 mL and 1.24, respectively, whereas the DPPH and hydroxyl radical scavenging activities of MLE were measured to be 88.89% and 22.10%, respectively. Prophylactic i.v. treatment with MLE resulted in a dose-dependent and significant inhibition of lung metastasis. Specifically, a MLE dose of 200 ug per mouse resulted in an 88.90% inhibition of lung metastasis. For the cytotoxicity assay, MLE doses up to 100 ug/mL were not shown to affect the growth of normal murine splenocytes. Additionally, the survival of normal cells was not affected at MLE doses below 500 ug/mL. However, MLE doses up to 500 ug/mL reduced the percentage of tumor cell growth for B16BL6 (67% alive) and colon26-M3.1 (62% alive) cells.
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