Zeolite 4A, a Synthetic Silicate, Suppresses Melanogenesis through the Degradation of Microphthalmia-Associated Transcription Factor by Extracellular Signal-Regulated Kinase Activation in B16F10 Melanoma Cells
- Authors
- Shin, Yong Jae; Han, Chang-Soo; Lee, Chang Seok; Kim, Hong-Sook; Ko, Seong-Hee; Hwang, Seung Kyun; Ko, Seong-Gyu; Shin, Jong Wook; Ye, Sang-Kyu; Chung, Myung-Hee
- Issue Date
- Jan-2010
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- melanogenesis; zeolite 4A; alpha-melanocyte-stimulating hormone; tyrosinase; microphthalmia-associated transcription factor; extracellular signal-regulated kinase
- Citation
- BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.33, no.1, pp 72 - 76
- Pages
- 5
- Journal Title
- BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Volume
- 33
- Number
- 1
- Start Page
- 72
- End Page
- 76
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22711
- DOI
- 10.1248/bpb.33.72
- ISSN
- 0918-6158
1347-5215
- Abstract
- Zeolite 4A, synthetic silicate, has been shown to exhibit diverse biological activities such as anti-cancer and anti-oxidant activity. In the present study, we report that the zeolite 4A may improve skin-whitening. We found that zeolite 4A inhibited melanin production in a dose-dependent manner, which has not cytotoxicity. Zeolite 4A also inhibited alpha-melanocyte-stimulating hormone (alpha-MSH)-induced melanin synthesis in B16F10 cells. Interestingly, zeolite 4A decreased alpha-MSH-induced tyrosinase activity in B16F10 cells, which did not inhibit tyrosinase activity under cell-free conditions. The results of this study indicate that zeolite 4A may reduce pigmentation by way of an indirect nonenzymatic mechanism. We also found that zeolite 4A decreased alpha-MSH-induced microphthalmia-associated transcription factor (MITF) and tyrosinase expression and that zeolite 4A induced the activation of extracellular signal-regulated kinase (ERK). These results suggest that the depigmenting effect of zeolite 4A may result from the down-regulation of MITF and tyrosinase expression by increasing ERK activity. The results thus provide evidence that zeolite 4A can be used as a potential skin-whitening agent.
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