Multipotent Progenitor Cells Derived From Human Umbilical Cord Blood Can Differentiate Into Hepatocyte-Like Cells in a Liver Injury Rat Model
- Authors
- Moon, Y. J.; Yoon, H. H.; Lee, M. W.; Jang, I. K.; Lee, D. -H.; Lee, J. -H.; Lee, S. -K.; Lee, K. -H.; Kim, Y. J.; Eom, Y. -W.
- Issue Date
- Dec-2009
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- TRANSPLANTATION PROCEEDINGS, v.41, no.10, pp 4357 - 4360
- Pages
- 4
- Journal Title
- TRANSPLANTATION PROCEEDINGS
- Volume
- 41
- Number
- 10
- Start Page
- 4357
- End Page
- 4360
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22848
- DOI
- 10.1016/j.transproceed.2009.08.053
- ISSN
- 0041-1345
1873-2623
- Abstract
- Umbilical cord blood (UCB), a rich source of hematopoietic stem cells, offers practical and ethical advantages. It has been reported that various adult stem cells transplanted into a damaged liver show characteristics of a hepatic lineage. In a previous study, we reported on novel UCB-derived adult stem cells, termed umbilical cord blood-derived multipotent progenitor cells (UCB-MPCs). We demonstrated that these cells were capable of differentiating into hepatocyte-like cells in vitro. To assess the hepatic differentiation capacity of UCB-MPCs, rat models of hepatic injury were generated using carbon tetra-chloride (CC14) with transplantation of cells into the liver. The transplanted cells successfully incorporated into the liver of the recipient animal differentiated into functional hepatocyte-like cells that expressed hepatocyte-specific markers, such as CK-18 and albumin. Moreover, human albumin was detected in the serum of the recipient rat model. These data indicated that UCB-MPCs were capable of displaying similar characteristics to those of functional hepatocytes in a recipient liver. UCB-MPCs may prove to be a useful, transplantable alternative for hepatic progenitor cells in both experimental and therapeutic applications.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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