Effects of a Preparation of Combined Glutathione-Enriched Yeast and Rice Embryo/Soybean Extracts on Ethanol Hangover
- Authors
- Lee, Heon-Sik; Song, Jugyeong; Kim, Tae Myoung; Joo, Seong Soo; Park, Dongsun; Jeon, Jeong Hee; Shin, Sunhee; Park, Hyoung Kook; Lee, Won Kyung; Ly, Sun Yung; Kim, Mee Ree; Lee, Do Ik; Kim, Yun-Bae
- Issue Date
- Dec-2009
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- alcohol hangover; alcohol-metabolizing enzymes; glutathione-enriched yeast; rice embryo/soybean
- Citation
- JOURNAL OF MEDICINAL FOOD, v.12, no.6, pp 1359 - 1367
- Pages
- 9
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- Volume
- 12
- Number
- 6
- Start Page
- 1359
- End Page
- 1367
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/22873
- DOI
- 10.1089/jmf.2008.1367
- ISSN
- 1096-620X
1557-7600
- Abstract
- The effects of a preparation of combined glutathione-enriched yeast (GEY) and rice embryo/soybean (RES) extracts (20:1), GEY/RES, on experimentally induced ethanol hangover were investigated in male Sprague-Dawley rats. To evaluate the preventive effects on hangover, rats were orally administered GEY/RES (50/2.5, 100/5, or 200/10 mg/kg) for 2 weeks. At 30 minutes after the final treatment, they were challenged with 3 mL/kg ethanol (15 mL of 20% in water/kg). The blood concentrations of alcohol and acetaldehyde were analyzed up to 7 hours postchallenge. Hepatic mRNA expression levels of alcohol-metabolizing enzymes, alcohol dehydrogenase (ADH), cytochrome P450 type 2E1 (CYP2E1), and aldehyde dehydrogenase (ALDH), were determined by real-time polymerase chain reaction. Additional rats were challenged with ethanol and, 60 minutes later, administered GEY/RES to evaluate alcohol clearance. Pretreatment with GEY/RES for 2 weeks reduced the blood concentrations of alcohol and acetaldehyde in a dose-dependent manner, lowering by 29.5% and 54.6% at the highest dose (200/10 mg/kg), respectively. The expressions of mRNAs for ADH and ALDH, the major alcohol-metabolizing enzymes, were markedly increased in the livers of rats administered GEY/RES for 2 weeks, whereas CYP2E1 mRNA was suppressed. Postchallenge treatment with GEY/RES enhanced the alcohol clearance rate by lowering blood concentrations of alcohol and acetaldehyde by 24% and 26.6%, respectively, for the highest dose group. GEY/RES remarkably eliminated 2,2-diphenyl-1-picrylhydrazyl hydrate radical and FeCl3-mediated lipid peroxidation in vitro and attenuated hepatic lipid accumulation following ethanol administration in vivo. Therefore, it is suggested that GEY/RES reduces the blood concentrations of alcohol and acetaldehyde not only by modulating alcohol-metabolizing enzymes, but also by exerting its antioxidant activity, and that GEY/RES could be a promising candidate for improvements of alcoholic hangover.
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