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A 2.7-kb Deletion in the Human NLRP10 Gene Exon 2 Occurred After the Human-Chimpanzee Divergence
- Authors
- Ha, Hye Jeong; Kim, Dong Seon; Hahn, Yoonsoo
- Issue Date
- Oct-2009
- Publisher
- SPRINGER/PLENUM PUBLISHERS
- Keywords
- Human; Chimpanzee; NLRP10; Molecular evolution; LINE-1
- Citation
- BIOCHEMICAL GENETICS, v.47, no.9-10, pp 665 - 670
- Pages
- 6
- Journal Title
- BIOCHEMICAL GENETICS
- Volume
- 47
- Number
- 9-10
- Start Page
- 665
- End Page
- 670
- ISSN
- 0006-2928
1573-4927
- Abstract
- NLRP10 is a member of the NLRP protein family, which is involved in inflammation and apoptosis. Genome sequence comparisons revealed that a 2.7-kb deletion occurred in the human NLRP10 gene exon 2 after the divergence of humans and chimpanzees, resulting in replacement of the entire 3' untranslated region with the flanking LINE-1 element. The human NLRP10 protein lost 30 or more amino acids that are conserved in primates at its carboxy-terminus. The structural modification of the NLRP10 gene might have played a role in development or enhancement of human-specific traits during evolution.
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Collections - College of Natural Sciences > Department of Life Science > 1. Journal Articles
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