Atherosclerotic Progression Attenuates the Expression of Nogo-B in Autopsied Coronary Artery: Pathology and Virtual Histology Intravascular Ultrasound Analysis
- Authors
- Lee, Wang-Soo; Kim, Sang-Wook; Hong, Soon-Auck; Lee, Tae-Jin; Park, Eon-Sub; Kim, Hyoung-Joong; Lee, Kwang Je; Kim, Tae Ho; Kim, Chee Jeong; Ryu, Wang Seong
- Issue Date
- Aug-2009
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Keywords
- Atherosclerosis; Nogo Protein; Ultrasonography, Interventional; Autopsy
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.24, no.4, pp 596 - 604
- Pages
- 9
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 24
- Number
- 4
- Start Page
- 596
- End Page
- 604
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23058
- DOI
- 10.3346/jkms.2009.24.4.596
- ISSN
- 1011-8934
1598-6357
- Abstract
- The relation of Nogo-B to atherosclerotic plaque progression is not well understood. Thus, the purpose of this study was to assess the expression of Nogo-B in fibro-atheromas (FA) of different stages, classified using virtual histology intravascular ultrasound (VH-IVUS) analysis in 19 autopsied cases of non-sudden cardiac death. VH-IVUS imaging analysis was performed 30 mm from the ostium of each coronary artery. VH-IVUS revealed 11 early FAs (34.5 +/- 8.3 yr), 12 late FAs (42.6 +/- 16.6 yr), 8 thick-cap FAs (TkCFAs) (46.4 +/- 11.1 yr), and 6 thin-cap FAs (TCFAs) (51.8 +/- 6.8 yr). TkCFAs and TCFAs were defined as advanced FA. FA progression advanced with age (P=0.04). VH-IVUS analysis of small, early FAs showed smaller necrotic cores and relatively less calcium compared to more advanced FAs with large necrotic cores (P < 0.001). Histopathology and immunohistochemical stains demonstrated that early or late FAs had smaller necrotic cores, less empty space of decalcification, and greater Nogo-B expression compared to advanced FAs (vs. early FA, P=0.013; vs. late FA, P=0.008, respectively). These findings suggest that FA progression is inversely associated with Nogo-B expression. Local reduction of Nogo-B may contribute to plaque formation and/or instability.
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