Association of Tumor Necrosis Factor-alpha with Fever and Pulmonary Lesion Score in Pigs Experimentally Infected with Swine Influenza Virus Subtype H1N2
- Authors
- Kim, Bongtae; Ahn, Kyoung Kyu; Ha, Yooncheol; Lee, Yong Hoon; Kim, Duyeol; Lim, Jeong Han; Kim, Sung-Hoon; Kim, Mi-Young; Cho, Kyung-Dong; Lee, Bog-Hieu; Chae, Chanhee
- Issue Date
- May-2009
- Publisher
- JAPAN SOC VET SCI
- Keywords
- fever; H1N2 Subtype; swine influenza Virus; tumor necrosis factor-alpha
- Citation
- JOURNAL OF VETERINARY MEDICAL SCIENCE, v.71, no.5, pp 611 - 616
- Pages
- 6
- Journal Title
- JOURNAL OF VETERINARY MEDICAL SCIENCE
- Volume
- 71
- Number
- 5
- Start Page
- 611
- End Page
- 616
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23196
- DOI
- 10.1292/jvms.71.611
- ISSN
- 0916-7250
1347-7439
- Abstract
- The relationship between tumor necrosis factor (TNF)-alpha level, body temperature, and pulmonary lesion score was determined in 3-week-old pigs inoculated intranasally with swine influenza virus (SIV) subtype H1N2. The expression of TNF-alpha was measured in bronchoalveolar lavage (BAL) fluids by enzyme-linked immunosorbent assay and lung tissues by immunohistochemistry. In BAL fluid, TNF-alpha concentration was maximal at 1 days post-inoculation (dpi), declined markedly by 3 dpi (P < 0.05) and steady thereafter. Mean rectal temperatures were above 40 degrees C for the infected groups at 1 dpi and declined markedly by 3 dpi. The body temperatures were correlated with the levels of TNF-alpha in BAL fluids from pigs experimentally infected with SIV (r(s)=0.9754, P < 0.05). The pulmonary lesion scores were correlated with the means of positive cells by immunohistochemistry for TNF-alpha (r(s)=0.9949, P < 0.001). The results Suggest that the expression of TNF-alpha protein plays an important role in induction of pulmonary lesion and clinical Sign Such as fever in SIV infection.
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Collections - College of Biotechnology & Natural Resource > School of Food Science and Technology > 1. Journal Articles
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