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Amphiphilic comb-like polymers based on poly(oxyethylene)s as drug-delivery carriers
- Authors
- Kim, Ki-Hyun; Lee, Jong-Chan; Lee, Jonghwi
- Issue Date
- Apr-2008
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- drug-delivery systems; micelles; non-linear polymers; particle size distribution; water-soluble polymers
- Citation
- MACROMOLECULAR BIOSCIENCE, v.8, no.4, pp 339 - 346
- Pages
- 8
- Journal Title
- MACROMOLECULAR BIOSCIENCE
- Volume
- 8
- Number
- 4
- Start Page
- 339
- End Page
- 346
- ISSN
- 1616-5187
1616-5195
- Abstract
- Comb-like polymers with biocompatible oxyethylene backbones and amphiphilic side groups were synthesized via polymer-analogous reactions. Using these polymers, indomethacin-loaded polymeric micelles were fabricated with various drug-to-polymer weight ratios using the oil-in-water emulsion technique. In addition, the size, size distribution, CMC, drug-loading content, and entrapment efficiency of the polymeric micelles were analyzed. The volume-weighted diameters of polymeric micelles ranged from 10 to 140 nm and were narrowly distributed for passive targeting drug delivery. The CMCs were lower (approximate to 10(-8) m) than for conventional. surfactants and block copolymers.
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