Prenatal increased asymmetric dimethylarginine is associated with placental heat-shock protein 70 and lectin-like oxidized low-density lipoprotein receptor-1 expression
- Authors
- Kim, Young Ju; Jeon, Yeo Jin; Ahn, Young Mo; Lee, Hwa Young; Woo, So Yeon; Park, Hye Sook; Ha, Eun Hee; Pang, Myung Geol
- Issue Date
- Nov-2007
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- ADMA; nitric oxide; HSP70; LOX-1; oxidative stress; placenta
- Citation
- ARCHIVES OF MEDICAL RESEARCH, v.38, no.8, pp 839 - 845
- Pages
- 7
- Journal Title
- ARCHIVES OF MEDICAL RESEARCH
- Volume
- 38
- Number
- 8
- Start Page
- 839
- End Page
- 845
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/23944
- DOI
- 10.1016/j.aremed.2007.05.005
- ISSN
- 0188-4409
1873-5487
- Abstract
- Background. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, induces endothelial dysfunction by reversibly blocking NO production from L-arginine. To elucidate the association of prenatal status of ADMA with placental heat-shock protein 70 (HSP70) and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in normal full-term pregnancies, we evaluated the expression of placental HSP70 and LOX-1. Methods. Tissue samples of placentas obtained from 60 normal-term pregnancies were categorized into 30 cases with a lower level of prenatal ADMA (0.28 +/- 0.07 mu M) and 30 cases with a higher level of prenatal ADMA (1.31 +/- 0.44 mu M). We evaluated the placental expression of HSP70 and LOX-1 with Western blot analysis and immunohistochemistry and determined the correlation between HSP70 and LOX-1. Results. We found that prenatal increased ADMA is associated with increased placental HSP70 and LOX-1 expression. Conclusions. We postulate that higher ADMA levels are associated with excessive levels of oxidative damage and stress markers (HSP, LOX-1) in placental tissues. (c) 2007 IMSS. Published by Elsevier Inc.
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