Extremely low frequency magnetic field induces hyperalgesia in mice modulated by nitric oxide synthesis
- Authors
- Jeong, Ji Hoon; Chan, Kum; Choi, Hee Jung; Park, Eon Sub; Sohn, Uy Dong
- Issue Date
- Feb-2006
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- extremely low frequency magnetic field; nitric oxide; hyperalgesia
- Citation
- LIFE SCIENCES, v.78, no.13, pp 1407 - 1412
- Pages
- 6
- Journal Title
- LIFE SCIENCES
- Volume
- 78
- Number
- 13
- Start Page
- 1407
- End Page
- 1412
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/24406
- DOI
- 10.1016/j.lfs.2005.07.006
- ISSN
- 0024-3205
1879-0631
- Abstract
- We investigated an effect of extremely low frequency magnetic field (ELF-MF, 60 Hz) oil hyperalgesia using hot plate test. The level of nitric oxide (NO) and the expression of nitric oxide synthase (NOS) were measured to determine if ELF-MF is engaged in NO mediated pain mechanism. Additionally, the involvement of Ca2+-dependent NO pathway in ELF-MF induced hyperalgesia was evaluated by blocking Ca2+ sources with NMDA receptor antagonist and Ca2+ channel blocker. The exposure of mice to ELF-MF lowered pain threshold and elevated NO synthesis in brain and spinal cord. An NOS inhibitor blocked these effects of ELF-MF with attenuating the reduction of pain threshold and the rise of NO level in brain and spine by the exposure of ELF-MF. The hyperalgesic effects of ELF-MF were also blocked by a Ca2+ channel blocker, nimodipine, but not by a NMDA receptor antagonist, MK-801. The expression of Ca2+-dependent nNOS and eNOS and Ca2+-independent iNOS were not changed by ELF-MF. These results indicated that the exposure of ELF-MF might cause Ca2+-dependent NOS activation, which then induces hyperalgesia with the increase in NO synthesis. In conclusion, ELF-MF may produce hyperalgesia by modulating NO synthesis via Ca2+-dependent NOS. (c) 2005 Elsevier Inc. All rights reserved.
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Collections - College of Pharmacy > School of Pharmacy > 1. Journal Articles
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